GDF-8 Peptide

Human Growth Peptides GDF-8 For Body Building

GDF-8 Peptide Profile:
Product name: GDF-8 (Growth Differentiation Factor 8 Myostatin)
Purity: 85%
Specification: 1mg
Storage:2-8 degree centigrade refrigerator
Package: 10 Vials/Kit
Deliver:1 working day for ready goods,7 days to your destination.
Pacakge:1kit=10vials Alumnium foil+bubble+carton
Country of Origin: China
Appearance:white powder
Packing:1mg/vial

GDF-8 Peptide Description:
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells’ autocrine function to inhibit myogenesis: Muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

GDF-8 Peptide Usage:
1) The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin “knockout” mice have approximately twice as much muscle as normal mice. These mice were subsequently named “mighty mice”.
2) Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3′ UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.
3) Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or “pro-domain” portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family – SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.

GDF-8 Peptide Dosage:
Doses of Myostatin propeptide have been tested mice and it has shown an optimal increase of muscle mass at a dose of 20 mg/kg. It can be used every 5 days for 25 five days.